Are you craving comfort food after a long week? This Cajun chicken pasta is bursting with flavor and hits the spot! It combines the best of Cajun cooking with classic pasta comfort. Give it a try tonight; you won’t regret it!

Bowl full of cajun chicken pasta with sautéed vegetables on a wooden table.

Now, this recipe is almost made in one dish. I ended up sauteeing my vegetables in my skillet first, but if you want to truly use one dish, you can totally sautee them directly in the dutch oven as well!

Recipe with Pictures!

For this recipe, you’ll need 1 whole-cooked and shredded chicken. You can use leftover chicken or a rotisserie chicken or cook your own using your preferred method (boiling, poaching, baking, etc.).

Ingredients

  • 1 box fettuccine noodles 
  • 1 whole chicken, cooked and shredded (see notes below)
  • 2 tsp cajun seasoning, more if desired 
  • 4 tablespoons butter
  • 1 green pepper, thinly sliced 
  • 1 red pepper, thinly sliced 
  • 1 red onion, thinly sliced 
  • 4 cloves garlic, minced 
  • 4 Roma tomatoes, diced 
  • 1/4 cup white wine 
  • 1/4 cup red wine vinegar 
  • 2 cups chicken broth 
  • 1 cup heavy cream 
  • 1/2 cup cheddar cheese, shredded

Recipe Instructions

Step 1: Follow the package instructions to cook your fettuccine noodles. Drain them thoroughly and set them aside.

Step 2: Melt the butter in a cast iron skillet over medium heat. Add the sliced peppers, onion, and garlic. Sauté for 2-3 minutes, stirring occasionally, until they start to soften. Add the diced tomatoes and cook for another minute. Here, you’ll want to sprinkle in the Cajun seasoning.

Sauteeing the peppers and onions in a large cast iron skillet.

Step 3: Place your Dutch oven on the stovetop and heat it to medium heat. Pour in the white wine, red wine vinegar, and chicken broth. Whisk everything together until well combined. Let the mixture simmer for about 10 minutes to reduce the alcohol content.

Adding the red wine to the pot for the cajun chicken pasta.

Step 4: Stir the heavy cream into the simmering sauce in the Dutch oven. Once thoroughly combined, add the cooked pasta, shredded chicken, and shredded cheddar cheese. Toss everything together until evenly coated in the flavorful sauce.

Stirring all the pasta ingredients together after the noodles, chicken and vegetables are in the pot.

Step 5: Give the pasta a taste test and adjust the Cajun seasoning to your preference. Remember, you can always add more at the table for those who like a spicier kick.

I do like to garnish with fresh parsley, but that is totally optional. Serve and enjoy!

Here are a couple of tips when making this

Don’t overseason! Cajun seasoning tends to be on the spicy side, and it’s pretty easy to add more to your plate. With this recipe, following the exact measurements I use, my kids absolutely love it. But, I do add a few more dashes of seasoning to my plate, because I like it a tad spicier!

Leftovers: This recipe reheats beautifully! Store leftovers in an airtight container in the refrigerator for up to 3 days. When reheating, add a splash of chicken broth or milk to prevent the pasta from drying out.

For the cooked chicken: I cook up a small whole chicken in the instant pot or in the oven. It equates to about three large chicken breasts if you would rather go that route. We buy whole chickens locally, so that is what I use most often.

To shred the chicken, I just pull it apart with my hands, as you can see below! For a recipe on baking a whole chicken, check out this cajun chicken recipe.

Shredding chicken before adding the cajun seasoning and adding it to the pasta.

I just love all kinds of pasta!

This recipe was inspired by one of my favorite local restaurants. While I kind of went a different direction, the Cajun flavors were definitely the starting point!

I’m always looking for ways to add variety to our pasta night routine, and this dish definitely fits the bill! If you’re a fan of my Chicken Pesto Pasta or my seasonal Venison Pasta, this recipe is sure to become another favorite.

Overall, I think this dish is going to be added to the regular meal rotation!

If you made this recipe and loved it, I would love for you to come back and leave a review!

Bowl full of cajun chicken pasta with sautéed vegetables on a wooden table.

Cajun Chicken Pasta

Laura Ascher
This cajun chicken pasta is packed with delicious flavors and is so easy to make! This is the perfect recipe for leftover chicken!
5 from 1 vote
Prep Time 15 minutes
Cook Time 45 minutes
Total Time 1 hour
Course Main Course
Cuisine American
Servings 8
Calories 629 kcal

Equipment

Ingredients
  

  • 1 box fettuccine noodles
  • 1 whole chicken cooked and shredded, approx 2-3 pounds
  • 2 teaspoons cajun seasoning more if desired
  • 4 tablespoons butter
  • 1 green bell pepper thinly sliced
  • 1 red bell pepper thinly sliced
  • 1 red onion thinly sliced
  • 4 cloves garlic minced
  • 4 roma tomatoes diced
  • 1/4 cup white wine
  • 1/4 cup red wine vinegar
  • 2 cups chicken broth
  • 1 cup heavy cream
  • 1/2 cup cheddar cheese shredded

Instructions
 

  • For this recipe, you’ll need one whole-cooked and shredded chicken. You can use leftover chicken, rotisserie chicken or cook your own using your preferred method. See my cooking method options below!
  • Cook fettuccine noodles according to package directions. Drain and set aside.
  • Melt butter in a cast iron skillet over medium heat. Sauté peppers, onion, and garlic for 2-3 minutes, stirring occasionally. Add tomatoes and cook for another minute. Sprinkle in Cajun seasoning.
  • Heat Dutch oven to medium heat. Pour in white wine, red wine vinegar, and chicken broth. Whisk until combined and simmer for about 10 minutes.
  • Stir heavy cream into the simmering sauce in the Dutch oven. Add cooked pasta, shredded chicken, and shredded cheddar cheese. Toss to coat.
  • Taste test and adjust Cajun seasoning as desired. Serve. Garnish with fresh parsley!

Notes

If you don’t have a whole cooked chicken on hand, you can substitute it for three large chicken breasts cooked using your preferred method. You can also try one of these cooking methods below!
As you’re simmering the broth, wait to add the cream until the alcohol smell is gone. It usually takes about 10 minutes to cook off. 
Scroll up to the post for step-by-step pictures. 

Nutrition

Calories: 629kcalCarbohydrates: 46gProtein: 29gFat: 36gSaturated Fat: 17gPolyunsaturated Fat: 5gMonounsaturated Fat: 11gTrans Fat: 0.4gCholesterol: 176mgSodium: 401mgPotassium: 537mgFiber: 3gSugar: 5gVitamin A: 1878IUVitamin C: 39mgCalcium: 117mgIron: 2mg
Keyword cajun chicken pasta, easy cajun pasta with chicken, spicy chicken pasta
Tried this recipe?Mention @castironskilletcooking on Instagram
This website provides approximate nutrition information based on third party calculations and is only an estimate. Each recipe and nutritional value will vary depending on the brands, measuring methods and portion sizes per household. We recommend running the ingredients through whichever online nutritional calculator you prefer.

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